Tetanus Antitoxin Human Use Rx

Tetanus is a medical emergency requiring hospitalization, immediate treatment with human tetanus immune globulin (TIG) (or equine antitoxin if human immune globulin is not available), a tetanus toxoid (TT) booster, agents to control muscle spasm, and aggressive wound care and antibiotics. If immunoglobulin is not available, tetanus antitoxin (TAT; equine origin) in a single large dose should be given intravenously, after testing for hypersensitivity. Depending on the severity of disease, mechanical ventilation and agents to control autonomic nervous system instability may be required. An adequate airway should be maintained; tracheostomy, nasotracheal intubation, and/or mechanically assisted respiration, may be life-saving. Sedation and muscle relaxant drugs should be used as indicated to control muscle spasms. Active immunization may be initiated concurrently with treatment. [Ingredients]Equine tetanus immunoglobulin following pepsin digestion…